Antiphospholipid Syndrome



Disease as common as unknown, antiphospholipid syndrome predisposes to the formation of blood clots that will lead to thromboses and spontaneous abortions. Once detected, treatment can be introduced to prevent the occurrence of such events.


Epidemiology and mechanisms of the disease is practicing blood tests in patients with syphilis, a sexually transmitted disease that can cause damage to many organs, that was discovered in the early twentieth century called anticardiolipin antibodies. Later, it was realized that these antibodies were also present in patients with Systemic Lupus Erythematosus (immune complex disease involving the skin and sometimes other organs such as the kidney). Today, we know that 2-5% of the population has antibodies against phospholipid, a family of molecules involved in blood clotting. In the presence of these antiphospholipid antibodies against the patient present a blood "clot more easily," this leads to a third of cases of vascular thrombosis, or the formation of blood clots in either arteries or veins. In addition, female patients, where the prevalence is 2 times larger than in humans may notice recurrent miscarriages. Finally, these antibodies will interact with famous platelets (thrombocytes), whose numbers fall into the bloodstream.

There are two forms of the antiphospholipid syndrome: a primary form, that is to say without any underlying disease and form secondary to another disease (AIDS, cancer, autoimmune diseases).


Diagnosis: it is based on the presence of events such as vascular thrombosis, willingly repeated, spontaneous abortions or lack of platelets associated with abnormalities in blood tests (antibody diverse: lupus anticoagulant anti-beta 2 glycoprotein 1 ...).

Symptoms: It is essential to mention antiphospholipid syndrome where one finds the above symptoms. In addition, a non-negligible part of myocardial infarction and stroke in patients under age 50 is explained by the presence of this syndrome.

Treatment: Given this state of coagulation extreme care is to take pills that will make the blood more fluid: oral anticoagulants are indicated to prevent recurrence of thrombosis, acetylsalicylic acid to treat stroke and other immunosuppressive drugs (steroids, immunoglobulins) when platelets are too low.